Clinical correlates of depressive symptoms in familial Parkinson's disease
Identifieur interne : 000080 ( Main/Corpus ); précédent : 000079; suivant : 000081Clinical correlates of depressive symptoms in familial Parkinson's disease
Auteurs : Nathan Pankratz ; Karen S. Marder ; Cheryl A. Halter ; Alice Rudolph ; Cliff W. Shults ; William C. Nichols ; Tatiana ForoudSource :
- Movement Disorders [ 0885-3185 ] ; 2008-11-15.
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- KwdEn :
Abstract
Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini‐Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R2 = 0.33; P = 4 × 10−48). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22285
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Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini‐Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R2 = 0.33; P = 4 × 10−48). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Nathan Pankratz PhD</name><affiliations><json:string>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</json:string></affiliations></json:item><json:item><name>Karen S. Marder MD</name><affiliations><json:string>Department of Neurology, Columbia University and The Taub Institute, New York, USA</json:string></affiliations></json:item><json:item><name>Cheryl A. Halter MS</name><affiliations><json:string>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</json:string></affiliations></json:item><json:item><name>Alice Rudolph PhD</name><affiliations><json:string>Department of Neurology, University of Rochester, Rochester, New York, USA</json:string></affiliations></json:item><json:item><name>Cliff W. Shults PhD</name><affiliations><json:string>Department of Neurology, University of California, San Diego, La Jolla, California, USA</json:string><json:string>VA San Diego Healthcare System, San Diego, California, USA</json:string></affiliations></json:item><json:item><name>William C. Nichols PhD</name><affiliations><json:string>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</json:string><json:string>Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA</json:string></affiliations></json:item><json:item><name>Tatiana Foroud PhD</name><affiliations><json:string>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hoehn and Yahr stage</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>association</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>activities of daily living</value></json:item></subject><articleId><json:string>MDS22285</json:string></articleId><language><json:string>eng</json:string></language><abstract>Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini‐Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R2 = 0.33; P = 4 × 10−48). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>7.501</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1518</abstractCharCount><pdfWordCount>4777</pdfWordCount><pdfCharCount>30624</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>227</abstractWordCount></qualityIndicators><title>Clinical correlates of depressive symptoms in familial Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>23</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>2223</last><first>2216</first></pages><issn><json:string>0885-3185</json:string></issn><issue>15</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/mds.22285</json:string></doi><id>5F5D75A9C82637294749E14D567BFB032DFEB8B7</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/5F5D75A9C82637294749E14D567BFB032DFEB8B7/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/5F5D75A9C82637294749E14D567BFB032DFEB8B7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/5F5D75A9C82637294749E14D567BFB032DFEB8B7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Clinical correlates of depressive symptoms in familial Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note><note type="content">*Members of the Parkinson Study Group Investigators are listed as an Appendix.</note><note>Unknown funding agency - No. R01 NS37167;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Clinical correlates of depressive symptoms in familial Parkinson's disease</title><author><persName><forename type="first">Nathan</forename><surname>Pankratz</surname></persName><roleName type="degree">PhD</roleName><note type="correspondence"><p>Correspondence: Medical and Molecular Genetics, Indiana University, School of Medicine, Hereditary Genomics Division, 410 West 10th Street, MI‐4000, Indianapolis, Indiana 46202</p></note><affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</affiliation></author><author><persName><forename type="first">Karen S.</forename><surname>Marder</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Columbia University and The Taub Institute, New York, USA</affiliation></author><author><persName><forename type="first">Cheryl A.</forename><surname>Halter</surname></persName><roleName type="degree">MS</roleName><affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</affiliation></author><author><persName><forename type="first">Alice</forename><surname>Rudolph</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, University of Rochester, Rochester, New York, USA</affiliation></author><author><persName><forename type="first">Cliff W.</forename><surname>Shults</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, University of California, San Diego, La Jolla, California, USA</affiliation><affiliation>VA San Diego Healthcare System, San Diego, California, USA</affiliation></author><author><persName><forename type="first">William C.</forename><surname>Nichols</surname></persName><roleName type="degree">PhD</roleName><affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</affiliation><affiliation>Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA</affiliation></author><author><persName><forename type="first">Tatiana</forename><surname>Foroud</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini‐Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R2 = 0.33; P = 4 × 10−48). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>depression</term></item><item><term>Hoehn and Yahr stage</term></item><item><term>association</term></item><item><term>activities of daily living</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-01-07">Received</change><change when="2008-07-24">Registration</change><change when="2008-11-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5F5D75A9C82637294749E14D567BFB032DFEB8B7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>VA San Diego Healthcare System, San Diego, California, USA</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="US" type="organization"><unparsedAffiliation>Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">depression</keyword><keyword xml:id="kwd3">Hoehn and Yahr stage</keyword><keyword xml:id="kwd4">association</keyword><keyword xml:id="kwd5">activities of daily living</keyword></keywordGroup><fundingInfo><fundingAgency>Unknown funding agency</fundingAgency><fundingNumber>R01 NS37167</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini‐Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (<i>parkin</i>, <i>LRRK2</i>, <i>APOE</i>). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R<sup>2</sup> = 0.33; <i>P</i> = 4 × 10<sup>−48</sup>). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn3"><p>Potential conflict of interest: None reported.</p></note><note xml:id="fn4"><p>Members of the Parkinson Study Group Investigators are listed as an Appendix.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical correlates of depressive symptoms in familial Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Depression in Familial Parkinson Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Clinical correlates of depressive symptoms in familial Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Nathan</namePart><namePart type="family">Pankratz</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</affiliation><description>Correspondence: Medical and Molecular Genetics, Indiana University, School of Medicine, Hereditary Genomics Division, 410 West 10th Street, MI‐4000, Indianapolis, Indiana 46202</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karen S.</namePart><namePart type="family">Marder</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Columbia University and The Taub Institute, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cheryl A.</namePart><namePart type="family">Halter</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alice</namePart><namePart type="family">Rudolph</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, University of Rochester, Rochester, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cliff W.</namePart><namePart type="family">Shults</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, University of California, San Diego, La Jolla, California, USA</affiliation><affiliation>VA San Diego Healthcare System, San Diego, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William C.</namePart><namePart type="family">Nichols</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA</affiliation><affiliation>Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tatiana</namePart><namePart type="family">Foroud</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-11-15</dateIssued><dateCaptured encoding="w3cdtf">2008-01-07</dateCaptured><dateValid encoding="w3cdtf">2008-07-24</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">42</extent><extent unit="words">5690</extent></physicalDescription><abstract lang="en">Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini‐Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R2 = 0.33; P = 4 × 10−48). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="content">*Members of the Parkinson Study Group Investigators are listed as an Appendix.</note><note type="funding">Unknown funding agency - No. R01 NS37167; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>depression</topic><topic>Hoehn and Yahr stage</topic><topic>association</topic><topic>activities of daily living</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>15</number></detail><extent unit="pages"><start>2216</start><end>2223</end><total>7</total></extent></part></relatedItem><identifier type="istex">5F5D75A9C82637294749E14D567BFB032DFEB8B7</identifier><identifier type="DOI">10.1002/mds.22285</identifier><identifier type="ArticleID">MDS22285</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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